Actionable, Equitable Testing.
NxGen MDx is a medical laboratory dedicated to providing high-quality genetic screening and pathogen testing. We ensure that patients everywhere have access to equitable screens and tests that can improve their reproductive and overall health.
What is Carrier Screening?
Carrier screening looks at your DNA to determine if you are a carrier of any autosomal recessive conditions (such as cystic fibrosis) or X-linked conditions (such as fragile X). Carriers are generally healthy and typically don’t show symptoms. However, if both reproductive partners are carriers of the same condition, there is a risk their baby could be affected by it.
Two reproductive partners who both carry the same autosomal recessive condition have a 25% chance of having a child affected by that condition. With X-linked conditions, if the mother is a carrier, there is a 50% chance that male children will be affected by that condition.
Autosomal Recessive Inheritance
X-Linked Inheritance
Learn About Your Reproductive Risk
%
of babies born with a genetic condition have no known family history of it*
When performed before or during pregnancy, carrier screening allows you and your healthcare provider to:
- Learn your child’s risk of inherited genetic conditions
- Improve preconception, pregnancy, and postnatal planning
- Choose the right birthing team and location
- Get an earlier diagnosis and administer timely treatment
- Better manage your pregnancy
- Explore all your reproductive and pregnancy options
Actionable Information With NxGen MDx Carrier Screening
- Understand your results and make informed decisions with expert support from our board-certified genetic counseling team.
- Get clear answers about your insurance coverage and billing from our customer service team.
- Need help paying for screening? Apply for our Access for All Program.
How Has Carrier Screening Helped Others Plan & Prepare?
Staff was knowledgeable and were able to explain things in laymen’s terms so I could understand the results. Stacy was patient and thoughtful; I will definitely recommend NxGen MDx to everyone.
The genetic counselor I had was very knowledgeable and eased my mind on all potential questions! Was courteous and professional and made sure no stone was left unturned with potential risks. Very happy I got the tests!
Casey, our genetic counselor, was very communicative, personable, and knowledgeable. She explained our test results in a clear and easy-to-understand way while addressing our concerns so that our minds could be at ease. Many thanks and we highly recommend.
In addition to providing all the facts and information I was curious about, the genetic counselor created a comfortable space for conversation about the more personal aspects of my motivations and implications for the results from the screening.
My genetic counselor spoke with me for an hour regarding my genetic test results. Her approach as well as her depth of knowledge were very impressive and helped me understand the implications of the results. She went above and beyond answering my questions for family planning purposes.
Need to Talk to Us?
When working with NxGen MDx, you have access to our experienced support staff ready to help with questions related to billing, insurance coverage, and more! Call us at (855) 776-9436 or click the link below to send us a message. Patients should direct all questions related to billing by contacting us directly.
Sources
*Blythe SA, Farrell PM. Advances in the diagnosis and management of cystic fibrosis. Clin Biochem. 1984 Oct;17(5):277–83.
1- Johansen Taber KA, Beauchamp KA, Lazarin GA, Muzzey D, Arjunan A, Goldberg JD. Clinical utility of expanded carrier screening: results-guided actionability and outcomes. Genet Med. 2019 May;21(5):1041–8.
FAQs
What is the accuracy rate?
NxGen MDx offers some of the world’s most accurate tests for detecting genetic markers. As further assurance, many doctors only rely on best-in-class NxGen MDx genetic screening as their trusted tools for early family planning, giving couples peace of mind and a better outlook for the years ahead.
How is the test performed?
NxGen MDx utilizes the best available laboratory methods to perform testing on blood or saliva samples from each patient. A blood or saliva sample will be collected at your doctor’s office and then sent to the NxGen MDx laboratory. Additional testing may be recommended if preliminary results indicate you or your partner is a carrier for any of the tested conditions.
I have no family history of genetic disease. Am I still at risk?
Yes, the reality is that any person of childbearing age could be a carrier for a genetic condition, even without a family history of the disease. A carrier can pass any of these conditions on to their children. NxGen MDx utilizes state-of-the-art technology to provide you and your physician with the most accurate information to help you make educated family planning decisions.
What happens if my partner and I are at risk for having a child with a genetic disease?
Should test results indicate a positive risk, there are many options available to you. If you are planning to become pregnant, consider prevention options, such as in vitro fertilization or using donor eggs or sperm from an individual who is not a carrier. Other couples may choose to adopt a child. If you are pregnant, prenatal diagnostic tests will determine whether your baby is affected by the disorder and allow you to start targeted treatment right from birth to improve your baby’s health outcomes. Your doctor or a NxGen MDx genetic counselor can discuss these options in detail regarding your specific carrier status.
What is the NxGen MDx Informed Prenatal Screen?
It is a non-invasive prenatal screen (NIPS) that analyzes small amounts of DNA from your baby’s placenta known as cell-free DNA which are present in your blood. This screen detects if your baby has either too many or too few chromosomes (known as an aneuploidy) that could lead to a health issue. NIPS is considered to be appropriate for all pregnant women with a singleton or twin pregnancy regardless of age or personal history.
Placental DNA From Your Baby
Is Present In Your Blood
Why Should I Get This Screen?
NIPS can give you valuable insights into the genetic health of your baby as early as 10 weeks into your pregnancy. NIPS is very accurate, reduces the need for invasive diagnostic procedures, and poses no risk to your baby.
Whether you receive a low- or high-risk result, you and your healthcare provider can use it to help make educated decisions about your baby’s risk, management of your pregnancy, and delivery options.
Understanding Your Risk
Low-Risk
No Aneuploidy Detected
What if I get a Low-Risk Result?
Your pregnancy has a low risk of having the aneuploidies that the Informed Prenatal Screen looks for. Most pregnancies have a low-risk result.
High-Risk
Aneuploidy Detected
What if I get a High-Risk Result?
Your pregnancy has an increased risk for one or more of the aneuploidies that the Informed Prenatal Screen looks for. Your healthcare provider may discuss genetic counseling, diagnostic testing, and/or adjustments in managing your pregnancy.
What Does it Screen for?
- Trisomy 21 (Down Syndrome)
- Trisomy 18 (Edwards Syndrome)
- Trisomy 13 (Patau Syndrome)
- Sex Chromosome Aneuploidies
The Informed Prenatal Screen can also tell you your baby’s sex if desired, including twin pregnancies.*
Your doctor may recommend additional screening such as microdeletions (small chromosomal changes) or expanded aneuploidies (all chromosome analysis) if they believe it is necessary.
Talk to a Genetic Counselor
As a NxGen MDx client, you’ll have access to personal genetic counselors who can help explain the results of you screens and provide insight on how to move forward. To schedule a personal conference to discuss your screen results, call (855) 776-9436 or click the link below.
How has the NxGen MDx NIPS helped other patients?
The genetic counselor I had was very knowledgeable and eased my mind on all potential questions! Was courteous and professional and made sure no stone was left unturned with potential risks. Very happy I got the tests!
Casey, our genetic counselor, was very communicative, personable, and knowledgeable. She explained our test results in a clear and easy-to-understand way while addressing our concerns so that our minds could be at ease. Many thanks and we highly recommend.
In addition to providing all the facts and information I was curious about, the genetic counselor created a comfortable space for conversation about the more personal aspects of my motivations and implications for the results from the screening.
My genetic counselor spoke with me for an hour regarding my genetic test results. Her approach as well as her depth of knowledge were very impressive and helped me understand the implications of the results. She went above and beyond answering my questions for family planning purposes.
Staff was knowledgeable and were able to explain things in laymen’s terms so I could understand the results. Stacy was patient and thoughtful; I will definitely recommend NxGen MDx to everyone.
Interested in the NxGen MDx Informed Prenatal Screen?
Sources
*Presence/absence of chrY is detected at >99.9% accuracy. Fetal sex discrimination between, Male/Male, Male/Female, and Female/Female has an overall accuracy of 91%. -NxGen MDx Internal Data 2022.
What is Hereditary Cancer Testing?
While cancer is typically considered to be caused by a combination of biological, environmental and lifestyle factors, there is another component: genetic variants (changes in a gene) that you may have inherited from your parents.
Your personal and family history of cancer can help you determine whether or not hereditary cancer testing might be right for you. Examples of a strong personal or family history of cancer can include:
- Cancer at an early age
- Diagnosis of specific cancers
- The presence of rare cancers
- Multiple relatives with the same type of cancer.
- One relative diagnosed with multiple primary cancers.
Do any of these factors apply to you? Want to see if you are at risk?
The Hereditary Cancer Panel
The Hereditary Cancer Panel gives you a personalized risk assessment of your chance to develop hereditary cancer in your lifetime. This curated panel of 32 genes has been designed to give you clear and actionable information that you and your healthcare provider can use to develop a risk management plan.
Detection
Your risk assessment may change how often you get screenings and procedures done to detect cancer. Generally, the earlier that cancer is detected the more effective treatment will be.
Prevention
You and your healthcare provider may choose to have early preventative procedures, risk reducing surgeries, or medication to help prevent cancer from developing.
Education
Your risk assessment not only provides you with your lifetime risk for hereditary cancer but can also serve as a powerful education tool for your family, allowing them to take action and develop their own risk management plans.
Talk to a Genetic Counselor
As a NxGen MDx client, you’ll have access to board certified genetic counselors who can help explain the results of your screening and provide insight on how to move forward. To schedule a personal conference to discuss your screening results, call (855) 776-9436 or click the link below.
How as the NxGen MDx Hereditary Cancer Panel Benefitted Others?
My genetic counselor spoke with me for an hour regarding my genetic test results. Her approach as well as her depth of knowledge were very impressive and helped me understand the implications of the results. She went above and beyond answering my questions for family planning purposes.
Staff was knowledgeable and were able to explain things in laymen’s terms so I could understand the results. Stacy was patient and thoughtful; I will definitely recommend NxGen MDx to everyone.
The genetic counselor I had was very knowledgeable and eased my mind on all potential questions! Was courteous and professional and made sure no stone was left unturned with potential risks. Very happy I got the tests!
Casey, our genetic counselor, was very communicative, personable, and knowledgeable. She explained our test results in a clear and easy-to-understand way while addressing our concerns so that out minds could be at ease. Many thanks and we highly recommend.
In addition to providing all the facts and information I was curious about, the genetic counselors created a comfortable space for conversation about the more personal aspects of my motivations and implications for the results from the screening.
Interested in the NxGen MDx Hereditary Cancer Panel?
Determining the Cause of Vaginitis Symptoms can be Challenging
Vaginitis can be caused by an imbalance of normal bacteria, yeast, or infectious pathogens such as STIs.
These types of infections have similar symptoms.
| Bacterial Vaginosis (BV) An overgrowth of naturally occurring vaginal bacteria |
Candidiasis An overgrowth of naturally occurring vaginal yeast |
Trichomoniasis The most common curable STI |
|
|---|---|---|---|
| Odor | Unpleasant | Unpleasant | Unpleasant |
| Vaginal Irritation | Sometimes | Often | Sometimes |
| Discharge | Thin, gray, white, or green | Thick, white | Frothy, gray, yellow, or green |
| External Appearance | Normal | Red and inflamed | Red and inflamed |
59% of patients with bacterial vaginosis have tried to self-treat before seeing their doctor, but most vaginal infections do not have over-the-counter treatment options.1
The NxGen MDx Vaginosis Test looks for 99% of the causes of community-acquired vaginal infections, helping your doctor distinguish between different types of infections without relying on symptoms alone.
NxGen’s test includes information on:
-
-
- Bacterial vaginosis
- Aerobic vaginitis
- Yeast infections
- STIs
- Antibiotic resistance
-
NxGen MDx is the Test of Choice, Even for Challenging Infections
Vaginal infections often recur and can be difficult for your doctor to effectively treat.
%
of infections have multiple pathogens present
%
of more than 9,000 cases showed evidence of antibiotic resistance²
Ask your doctor about the NxGen MDx Vaginosis Test for a fast solution to even the most complicated vaginitis cases.
NxGen MDx Makes the Testing Process Quick and Easy
The NxGen MDx Vaginosis Test uses a single swab to collect a sample from your vaginal wall. This test is quick, easy, and less invasive that a pap smear that requires a swab from your cervix.
When your doctor uses NxGen MDx, you also get:
-
-
- Results in 24 hours
- Best-in-class customer service
- An affordable test with our Access for All program
-
Leaving a Vaginal Infection Untreated May Lead to Further Health Complications
Bacterial Vaginosis
Increased risk for STIs, pelvic inflammatory disease, low birth weight, and premature birth3
Yeast
Discomfort, may interfere with pregnancy, and pain during sex4
Trichomoniasis
Increased risk of additional STIs, pelvic inflammatory disease, low birth weight, and premature birth5
The NxGen Vaginosis Test helps your doctor resolve your infection and reduce the risk of further health complications.
Don’t wait to call your doctor if something feels wrong.
Interested in the NxGen MDx Vaginosis Test?
Sources
2- NxGen MDx. 2021. Data on file.
3- Administration UD of VA Veterans Health. Bacterial Vaginosis – Women’s Health Guide – Public Health [Internet]. [cited 2021 Dec 1]. https://www.publichealth.va.gov/infectiondontpassiton/womens-health-guide/bacterial-vaginosis.asp
4- Untreated Yeast Infection: Why It Should Be Diagnosed and Treated [Internet]. Healthline. 2020 [cited 2021 Dec 1]. https://www.healthline.com/health/untreated-yeast-infection
5- Trichomoniasis [Internet]. Healthgrades. 2014 [cited 2021 Dec 1]. https://www.healthgrades.com/right-care/sexual-health/trichomoniasis
Know the Symptoms of a UTI
There are many UTI symptoms that might bring you into your doctor’s office.1
| Pain | Discomfort | Urine Changes |
|---|---|---|
| Burning Sensation | Persistent urge to urinate | Strong smell |
| Pelvic pain | Frequent and small amounts of urine | Color changes |
| Pain | Discomfort | Urine Changes |
|---|---|---|
| Burning Sensation | Persistent urge to urinate | Strong smell |
| Pelvic pain | Frequent and small amounts of urine | Color changes |
If you are experiencing any of these symptoms, reach out to your doctor and ask about UTI testing.
UTIs Can Be Difficult to Treat Effectively
While most UTIs can be resolved by your doctor, up to 30% of patients will see their symptoms return do to an inaccurate or incomplete diagnosis, requiring another visit to the doctor’s office.2 Recurrent UTIs can be caused by having multiple pathogens present or an infection that is resistant to antibiotics, both of which are common.
%
of UTIs have evidence of antibiotic resistance³
%
of UTIs are caused by more than one pathogen³
NxGen MDx’s UTI Test Leads to Effective Treatment
The NxGen MDx UTI Test helps diagnose co-infections by simultaneously testing for pathogens that cause 99% of community-acquired infections and resistance to antibiotics, reducing the chance of your infection returning.
With NxGen MDx, your doctor can prescribe an optimized treatment plan to clear your infection and help keep it from returning.
When your doctor uses NxGen MDx, you also get:
- Best-in-class customer service
- An affordable test with our Access for All program
Prevention and Treatment of UTIs
How You Can Prevent a UTI
A UTI is caused by pathogens infecting the urinary tract system, most often the bladder. While not all UTIs are preventable, talk to your doctor about some hygiene habits1 that can help reduce the risk of developing a UTI:
- Urinating after sex
- Wiping from front to back after urination
- Taking showers instead of baths
- Avoiding douches, sprays, or perfumed soaps in the genital area
Leaving a UTI Untreated May Lead to Further Health Complications
Untreated UTIs can develop into more serious infections that can cause lasting consequences. Without effective treatment, you may be at risk of:
- Kidney infections (pyelonephritis)4
- Pregnancy complications such as preterm labor, anemia, and severe kidney infections that could be fatal to the mother and baby4
- Renal scarring and injury, especially in children5
Interested in the NxGen MDx UTI Test?
Sources
1 – Mayo Clinic. Urinary Tract Infection (UTI) – Symptoms and Causes [Internet]. [cited 2021 Dec 14]. https://www.mayoclinic.org/diseases-conditions/urinary-tract-infection/symptoms-causes/syc-20353447
2 – Klein and Hultren. 2020. Urinary Tract Infections: Microbial Pathogenesis, Host-Pathogen Interactions and New Treatment Strategies. Nature Reviews Microbiology. 18:211-226
3 – NxGen MDx. 2021. Data on file. n>1200
4 – Habak PJ, Griggs J. Urinary Tract Infection In Pregnancy. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 [cited 2021 Dec 21]. http://www.ncbi.nlm.nih.gov/books/NBK537047/
5 – Shaikh N, Haralam MA, Kurs-Lasky M, Hoberman A. Association of Renal Scarring With Number of Febrile Urinary Tract Infections in Children. JAMA Pediatrics. 2019 Oct 1;173(10):949–52.